KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EPS8
All Species:
13.64
Human Site:
S538
Identified Species:
37.5
UniProt:
Q12929
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12929
NP_004438.3
822
91882
S538
Q
P
K
K
Y
A
K
S
K
Y
D
F
V
A
R
Chimpanzee
Pan troglodytes
XP_528750
1001
111581
R726
T
S
N
R
H
I
D
R
N
Y
E
P
L
K
T
Rhesus Macaque
Macaca mulatta
XP_001091077
1055
116825
S763
Q
P
K
K
Y
A
K
S
K
Y
D
F
V
A
R
Dog
Lupus familis
XP_534881
791
88639
S507
Q
P
K
K
Y
A
K
S
K
Y
D
F
V
A
R
Cat
Felis silvestris
Mouse
Mus musculus
Q08509
821
91720
S537
Q
P
K
K
Y
A
K
S
K
Y
D
F
V
A
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416405
831
92642
K541
T
Q
S
K
K
Y
A
K
C
K
Y
E
F
M
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956536
804
88650
V526
G
A
G
A
S
G
Y
V
P
N
N
I
L
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392229
880
100126
A515
R
T
A
G
M
E
R
A
Q
E
A
W
L
D
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785396
970
107261
R696
N
G
N
G
Y
H
Q
R
Q
S
S
D
S
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.7
76.1
91.1
N.A.
88.9
N.A.
N.A.
N.A.
79.7
N.A.
51.8
N.A.
N.A.
28.8
N.A.
25.5
Protein Similarity:
100
79
77.1
93.4
N.A.
94.8
N.A.
N.A.
N.A.
88.5
N.A.
66.9
N.A.
N.A.
47.2
N.A.
42.3
P-Site Identity:
100
6.6
100
100
N.A.
100
N.A.
N.A.
N.A.
6.6
N.A.
0
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
100
33.3
100
100
N.A.
100
N.A.
N.A.
N.A.
6.6
N.A.
13.3
N.A.
N.A.
40
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
12
12
0
45
12
12
0
0
12
0
0
45
12
% A
% Cys:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
12
0
0
0
45
12
0
12
12
% D
% Glu:
0
0
0
0
0
12
0
0
0
12
12
12
0
12
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
45
12
0
0
% F
% Gly:
12
12
12
23
0
12
0
0
0
0
0
0
0
0
12
% G
% His:
0
0
0
0
12
12
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
0
0
0
0
0
12
0
0
12
% I
% Lys:
0
0
45
56
12
0
45
12
45
12
0
0
0
12
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
34
12
0
% L
% Met:
0
0
0
0
12
0
0
0
0
0
0
0
0
12
0
% M
% Asn:
12
0
23
0
0
0
0
0
12
12
12
0
0
0
0
% N
% Pro:
0
45
0
0
0
0
0
0
12
0
0
12
0
0
0
% P
% Gln:
45
12
0
0
0
0
12
0
23
0
0
0
0
0
0
% Q
% Arg:
12
0
0
12
0
0
12
23
0
0
0
0
0
0
45
% R
% Ser:
0
12
12
0
12
0
0
45
0
12
12
0
12
0
0
% S
% Thr:
23
12
0
0
0
0
0
0
0
0
0
0
0
0
12
% T
% Val:
0
0
0
0
0
0
0
12
0
0
0
0
45
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% W
% Tyr:
0
0
0
0
56
12
12
0
0
56
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _